The Snipper 2.5

app suite


Excel format required


Forensic MPS AIMs Panel Reference Sets


The training sets provided for each forensic MPS ancestry panel have been constructed from published 1000 Genomes Phase III and Simons Foundation Genome Diversity Project genotypes. Populations are grouped by continental region, but can be analysed individually by referring to the sample codes listed in column 3 and detailed in the 1000 Genomes sample spreadsheet.
The 1000 Genomes American samples are Peruvians from Lima (PEL) only, as these show the highest levels of Native American ancestry and are ranked accordingly: rows 1-18 show >99% cluster membership; 19-55 >70%; 56-85 <70% (STRUCTURE analysis of 580K SNPs). Users can remove or retain PEL rows as their analyses require.
The fourteen Oceanians (OCE) are all HGDP-CEPH Panel individuals from Papua New Guinea identified by their CEPH-HGDP sample numbers.
The SNP data listed in blue in the ForenSeq DNA Signature Prep Kit indicate genotypes from the opposite-strand to the reference sequence, as reported by the Illumina software.

With all of the above in mind, download the adequate file: Applied Biosystems Precision ID Ancestry Panel 165, EUROFORGEN 127 Global AIMs or Illumina ForenSeq DNA Signature Prep Kit 55 (ForenSeq calls). Then paste your profiles as extra rows ending in 0 into it, and modify the number of individuals in first leftmost cell accordingly. At this stage you will have a hybrid profile and training set file to analyse. Then go to the multiple profiles tool in Snipper and input the resulting file.